| Popis: |
Candidiasis: A disease, which though common yet often neglected, has caused more havoc than reported and with the increase in antimicrobial resistance, antifungal agents that are more effective are to be used. The aim of this work is to identify Candida species causing oral thrush and vaginal candidiasis in Awka, Nigeria and evaluate the effect of Fluconazole and Nystatin in-vitro against them. Using standard microbiological tests in identification, 80 samples (43.24%) were positive for Candida out of the 185 samples gotten from the study subjects. Candida albicans (55%), C.tropicalis (35%) and C.glabrata (10%) were isolated from the oral cavity while Candida albicans (35%), C.krusei (31.67%), C.tropicalis (15%), C.dublinensis (8.33%), C.glabrata (5.00%), and C.parapsilosis (5.00%) were isolated from the vagina. Fluconazole (50µl) and Nystatin (100 Units) were employed in the anticandidal sensitivity test using agar well diffusion method. More susceptibility to Nystatin than Fluconazole was recorded. From the oral cavity, C.tropicalis was the most susceptible while C.glabrata and C.parapsilosis were the most susceptible species from the HVS samples. This reveals the increase in isolation of non-albicans Candida (NAC) and their growing resistance to Fluconazole which is commonly used hence the need to employ Nystatin as a first line drug for the treatment of oral thrush and vaginal candidiasis. |
