Novel adenyl dinucleotides with antitumour activity and a method for preparing thereof

Autor:	BASILE G, BENATTI U, BRUZZONE S, DAMONTE G, DE FLORA A, FRANCO L, GUIDA L, ZOCCHI E., FATTORUSSO, ERNESTO, TAGLIALATELA SCAFATI, ORAZIO
Přispěvatelé:	Basile, G, Benatti, U, Bruzzone, S, Damonte, G, DE FLORA, A, Fattorusso, Ernesto, Franco, L, Guida, L, TAGLIALATELA SCAFATI, Orazio, Zocchi, E.
Rok vydání:	2006
Popis:	The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+ .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3730::d30169ba33f8a3570384c553c54f401a http://hdl.handle.net/11588/122592 Zobrazit plný text záznamu