Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

Autor:	D'ERRICO, STEFANO, OLIVIERO, GIORGIA, BORBONE, NICOLA, NICI, FABRIZIA, MAYOL, LUCIANO, PICCIALLI, VINCENZO, PICCIALLI, GENNARO, Di Gennaro, Elena, Zotti, Andrea Ilaria, Budillon, Alfredo, Cerullo, Vincenzo
Přispěvatelé:	D'Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Di Gennaro, Elena, Zotti, Andrea Ilaria, Budillon, Alfredo, Cerullo, Vincenzo, Nici, Fabrizia, Mayol, Luciano, Piccialli, Vincenzo, Piccialli, Gennaro
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Platinum Nucleosides Antitumor agents Medicinal chemistry
Popis:	Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3730::cc6dfeffef32031baf13731e93a3336b http://hdl.handle.net/11588/612816 Zobrazit plný text záznamu