| Autor: |
DE MARINO, SIMONA, ZOLLO, FRANCO, M. Iorizzi, C. Roussakis, C. Debitus |
| Přispěvatelé: |
DE MARINO, Simona, M., Iorizzi, Zollo, Franco, C., Roussaki, C., Debitus |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Popis: |
Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-NG) with IC50 values of < 3.3-5.7 mu g/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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