| Autor: |
Guillon, J, Vincenzi, M, Ronga, L, ROSSI, FILOMENA, Savrimoutou, S, Moreau, S, Marchivie, M. |
| Přispěvatelé: |
Guillon, J, Vincenzi, M, Ronga, L, Rossi, Filomena, Savrimoutou, S, Moreau, S, Marchivie, M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Popis: |
The X-ray crystal structure of 3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole, a compound that showed high cytotoxic potential against various leukemia cell lines, was established. The 3D spatial determination confirmed the structure in the solid state. It crystallizes inthe triclinic space group P-1 with cell parameters a=9.572(7) Å, b=11.091(2) Å, c=15.976(4) Å, α=92.53(2), β=105.45(3), γ=94.65(3), V=1625.6(13) Å3 and Z=2. The crystal structure was refined to final values of R1=0.0638 and wR2=0.1800. The crystal packing is controlled by intermolecular hydrogen bonding and C-H interactions. In addition, these new data could be further used to clarify the mechanism of action, implicating the antiproliferative effect of this new synthetic indole derivative on human leukemic cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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