| Autor: |
L. Cerofolini, V. Borsi, M. Fragai, AMATO, JUSSARA, PAGANO, BRUNO, RANDAZZO, ANTONIO |
| Přispěvatelé: |
L., Cerofolini, Amato, Jussara, V., Borsi, Pagano, Bruno, Randazzo, Antonio, M., Fragai |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Popis: |
DNA-minor-groove-binding ligands are potent antineoplastic molecules. The antibiotic distamycin A is the prototype of one class of these DNA-interfering molecules that have been largely used in vitro. The affinity of distamycin A for DNA is well known, and the structural details of the complexes with some B-DNA and G-quadruplex-forming DNA sequences have been already elucidated. Here, we show that distamycin A binds S100β, a protein involved in the regulation of several cellular processes. The reported affinity of distamycin A for the calcium(II)-loaded S100β reinforces the idea that some biological activities of the DNA-minor-groove-binding ligands arise from the binding to cellular proteins. Copyright © 2015 John Wiley & Sons, Ltd. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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