| Autor: |
BILO, LEONILDA, R. Meo, P. Ruosi, M. F. de Leva, E. Nicolella, V. Macchia |
| Přispěvatelé: |
Bilo, Leonilda, R., Meo, P., Ruosi, M. F., de Leva, E., Nicolella, V., Macchia |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Popis: |
Purpose: Hormonal fluctuations related to menstrual cycle and pregnancy modulate electrical cerebral activity, and in particular in women with epilepsy, may influence paroxysmal activity (PA). The aim of this study was to evaluate the modifications of PA and of absolute power of alpha rhythm (APAR) during the menstrual cycle and pregnancy in 3 women with idiopathic generalised epilepsy (IGE). Methods: None of the 3 women with IGE were treated with antiepileptic drugs. All were studied during a menstrual cycle, and patient 3 was also evaluated during the course of pregnancy and puerperium. Serial determinations of sex hormones were carried out during menstrual cycles/pregnancy/puerperium, with EEG recordings performed on the same days as the hormonal study. During menstrual cycles the study was performed daily (only a few days were missed for each patient), during pregnancy it was carried out every month and during puerperium every week. Results: All menstrual cycles studied were ovulatory and showed a significant increase of PA in the periovulatory and/or perimenstrual period; no significant correlations were observed between PA and reproductive hormones, apart from FSH in 1 patient. In all patients APAR showed a significant increase on ovulation day, coinciding with the LH surge. During pregnancy PA was poorly represented, showing a dramatic increase near delivery, while APAR showed a gradual and significant increase and withdrawal on the day of delivery. Conclusion: Sex hormone fluctuations, particularly when peak-shaped and short lasting, exert a more evident influence on APAR than on AP. Gradual changes of hormonal levels have minor repercussions on neurophysiological parameters. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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