NK expansion, HLA-E expression and CD14+CD56+ monocytes in a Myelodysplastic Syndrome Patient

Autor:	Terrazzano G, Palatucci AT, Giovazzino A, Annunziatella M, Vitagliano O, RUBINO, VALENTINA, ALFINITO, FIORELLA, RUGGIERO, GIUSEPPINA
Přispěvatelé:	Terrazzano, G, Rubino, Valentina, Palatucci, At, Giovazzino, A, Annunziatella, M, Vitagliano, O, Alfinito, Fiorella, Ruggiero, Giuseppina
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	human leukocyte antigens-E CD94/NKG2 receprtor natural killer immune-mediated etiopathogenesi myelodysplastic syndrome
Popis:	Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14+CD56+ monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14+CD56+ monocytes in BM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3730::903cc61198f5e3d4d59ecf737ad80a0d http://hdl.handle.net/11588/561190 Zobrazit plný text záznamu