Pulmonary Hypertension in Transcatheter Mitral Valve Repair for Secondary Mitral Regurgitation: The COAPT Trial
| Autor: | Ben-Yehuda O., Shahim B., Chen S., Liu M., Redfors B., Hahn R. T., Asch F. M., Weissman N. J., Medvedofsky D., Puri R., Kapadia S., Sannino A., Grayburn P., Kar S., Lim S., Lindenfeld J., Abraham W. T., Mack M. J., Stone G. W. |
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| Přispěvatelé: | Ben-Yehuda, O., Shahim, B., Chen, S., Liu, M., Redfors, B., Hahn, R. T., Asch, F. M., Weissman, N. J., Medvedofsky, D., Puri, R., Kapadia, S., Sannino, A., Grayburn, P., Kar, S., Lim, S., Lindenfeld, J., Abraham, W. T., Mack, M. J., Stone, G. W. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Heart Failure Heart Valve Prosthesis Implantation Cardiac Catheterization Prognosi Risk Factor Hypertension Pulmonary Mitral Valve Insufficiency Middle Aged Risk Assessment Severity of Illness Index mitral valve repair Treatment Outcome Postoperative Complications transcatheter Echocardiography pulmonary hypertension Mitral Valve Female mitral regurgitation Human |
| Popis: | Background: Pulmonary hypertension worsens prognosis in patients with heart failure (HF) and secondary mitral regurgitation (SMR). Objectives: This study sought to determine whether baseline pulmonary hypertension influences outcomes of transcatheter mitral valve repair (TMVr) in patients with HF with SMR. Methods: In the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial, 614 patients with HF with moderate-to-severe or severe SMR were randomized to TMVr with the MitraClip plus guideline-directed medical therapy (GDMT) (n = 302) versus GDMT alone (n = 312). Baseline pulmonary artery systolic pressure (PASP) estimated from echocardiography was categorized as substantially increased (≥50 mm Hg) versus not substantially increased ( |
| Databáze: | OpenAIRE |
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