| Přispěvatelé: |
L., Russo, L., Vozzella, I. G., Savino, S., Di Palma, Sarnelli, Giovanni, Cuomo, Rosario |
| Popis: |
Background and aim: Correlation between the effectiveness of PHGG and patient characteristics, such as age, gender and BMI, was not evaluated. We aimed to investigate the effect of PHGG in symptom relief on constipationpredominant IBS patients stratified by age (< and >45 y), gender and BMI (< and > 25 kg/m2). Material and methods: Thirty IBS patients (22 F) were recruited according to the Rome III criteria. The study was planned with a 2-week (run-in period) followed by a 4-week treatment with PHGG. During both periods, patients filled a daily questionnaire to assess, by visual analogue scale (VAS), the pres- ence of abdominal pain/discomfort, bloating and the sensation of incomplete evacuation (IE). The number of evacuations per day (ED), the daily need for laxatives/enemas and stool consistency-form according to the Bristol scale (BS) were also evaluated. At the baseline and at the end of the study, all patients also performed RX colonic transit time (CTT). Results: PHGG significantly improved the overall symptom scores and im- proved BS and CTT (data not shown). The stratification of the patient based on age, gender and BMI showed a significant increase in ED in females (0.39 ± 0.18 vs 0.6 ± 0.09), in patients aged > 45 y (0.35 ± 0.09 vs 0.6 ± 0.08) andinthosewithBMI > 25 (0.34 ± 0.12 vs 0.60 ± 0.09) (all p < 0.05); ab- dominal bloating improved in males (2.6 ± 1.4 cm vs 1.6 ± 0.6, p < 0.05), in patients < 45 y (2.7 ± 2.2 vs 1.7 ± 1.1, p < 0.01) and in those with BMI < 25 (2.9 ± 2.2 vs 1.8 ± 1.1, p < 0.05). An improvement in the number of perceived IE/day in patients with a BMI =25 (0.6 ± 0.35 vs 0.4 ± 0.3, p < 0.05) was also found. In addition, a decreased needing of laxatives/enemas was recorded in females (0.14 ± 0.12 vs 0.07 ± 0.09, p < 0.05), in patients < 45 y (0.13 ± 0.12 vs 0.06 ± 0.08, p < 0.01) and in subjects with BMI < 25 (0.13 ± 0.12 vs 0.07 ± 0.09, p < 0.05). CCT significantly decreased at the end of study regardless of gender (males: 48 ± 8 hrs vs 39 ± 6; females: 45 ± 8vs39 ± 7) and of BMI ( < 25: 46 ± 8 vs 39 ± 7; =25: 47 ± 7vs39 ± 8), (all p < 0.05). BS improved in all patient subgroups. Conclusions: Demographic parameters such as age, BMI and gender seem to determine a different response to PHGG intake in constipated IBS patients |
