Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH

Autor:	Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, Katori T, Mancardi D, Thomas DD, Espey MG, Houk KN, Fukuto JM, Wink DA, TOCCHETTI, CARLO GABRIELE
Přispěvatelé:	Miranda, Km, Dutton, A, Ridnour, La, Foreman, Ca, Ford, E, Paolocci, N, Katori, T, Tocchetti, CARLO GABRIELE, Mancardi, D, Thomas, Dd, Espey, Mg, Houk, Kn, Fukuto, Jm, Wink, Da
Rok vydání:	2005
Popis:	The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3730::059cbb8e4e64772cd3bc24854b5415ce http://hdl.handle.net/11588/599264 Zobrazit plný text záznamu