| Autor: |
CANNIZZARO, Carla, BARRILE, Vita, DILIBERTO, Irene, LA BARBERA, Marco, PLESCIA, Fulvio, PROVENZANO, Giuseppa, TRINGALI, G. |
| Přispěvatelé: |
CANNIZZARO, C, BARRILE, V, DI LIBERTO, I, LA BARBERA, M, PLESCIA, F, PROVENZANO, G, TRINGALI, G |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
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| Popis: |
In the past, Acetaldehyde (ACD), the main metabolite of ethanol (ETOH), was mainly studied for its toxic and adverse effects (1). However, recently, ACD was reported to determine behavioural and neurochemical effects, following ETOH assumption in rodents (2, 3). Indeed, ACD enhances dopamine levels in nucleus accumbens, stimulates beta-endorphin release from hypothalamic cells, mediating alcohol reinforcing effects (4). Since little is known about the effects of ACD on other central neuropeptides, in this research we aimed to investigate ACD influence on hypothalamic corticotropin-releasing factor (CRF) release. In order to ascertain this hypothesis, different doses of ACD (1, 10, 3x10 microM) have been administered in incubated hypothalamic explants and CRF concentration have been detected by a radioimmunoassay. Our results show that, following 20 min of incubation at 37°C, ACD is able to significantly increase hypothalamic CRF release in a dose-dependent manner (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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