CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production
| Autor: | CACCAMO, Nadia Rosalia, MERAVIGLIA, Serena, LA MENDOLA, Carmela, DIELI, Francesco, SALERNO, Alfredo, BATTISTINI, L, BONNEVILLE, M, POCCIA, F, FOURNIE', JJ, BORSELLINO, G, KROCZEK, RA, SCOTET, E |
|---|---|
| Přispěvatelé: | CACCAMO, N, BATTISTINI, L, BONNEVILLE, M, POCCIA, F, FOURNIE', JJ, MERAVIGLIA, S, BORSELLINO, G, KROCZEK, RA, LA MENDOLA, C, SCOTET, E, DIELI, F, SALERNO, A |
| Jazyk: | English, Middle (1100-1500) |
| Rok vydání: | 2006 |
| Předmět: | |
| Popis: | Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|