| Autor: |
Totté, Philippe, Jongejan, Frans, De Gee, A.L.W., Wérenne, John |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Infection and Immunity |
| Popis: |
Cattle that resisted experimental heatntwater infection caused by the rickettsia #Cowdria ruminantium# produced significant levels of circulating alpha-interferon (IFN-alpha) whereas animals that died from heartwater did not. #In vitro#, recombinant bovine IFN.alpha) was found to significantly reduce the yield of #Cowdria# organisms in bovine endothelial cells, but even at a high concentration (1,000 U/ml), IFN-alpha did not completely prevent the growth of #Cowdria# organisms in these cells. This limited inhibitory effect of IFN-alpha is in agreement with the #in vivo# situation where an infectious process has to take place to induce a protective immune response. Our results suggest that IFN-alpha produced #in vivo# in response to #Cowdria# infection may represent an efficient way to slow down the infection and allow the animal to mount a protective immune response. IFN-alpha is the first endogenously produced factor shown to have anti-#Cowdria# activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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