Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome
Autor: | Enli Y, Fenkci SM, Fenkci V, Oztekin O |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
endocrine system diseases
Adolescent Adult Androgens/blood Blood Glucose/analysis Dyslipidemias/complications Female Follicle Stimulating Hormone/blood Glutathione/analogs & derivatives/blood Humans Hyperandrogenism/complications Insulin/blood Insulin Resistance Luteinizing Hormone/blood Malondialdehyde/blood Oxidative Stress Peroxidase/blood Polycystic Ovary Syndrome/complications/*physiopathology Sex Hormone-Binding Globulin/analysis Superoxide Dismutase/blood Young Adult alpha-2-HS-Glycoprotein nutritional and metabolic diseases |
Popis: | This study was designed to determine serum Fetuin-A levels and establish whether serum Fetuin-A level is related with insulin resistance, oxidative stress, ovarian hyperandrogenism and dyslipidemia in women with polycystic ovary syndrome (PCOS). Twenty-two patients with PCOS and twenty-one healthy control women were evaluated in this controlled clinical study. Serum Fetuin-A, lipid fractions, glucose, insulin, malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), superoxide dismutase (SOD) and other hormone (gonadotropins, androgens) levels were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-R). The women with PCOS had significantly higher serum fasting glucose, insulin, luteinizing hormone (LH), MDA, Fetuin-A levels, and LH/follicle-stimulating hormone (FSH) ratio, free androgen index (FAI), HOMA-IR than healthy women. However, sex hormone-binding globulin (SHBG) and GSH levels were significantly lower in patients with PCOS compared with controls. Fetuin-A was positively correlated with insulin, HOMA-IR and FAI. Multiple regression analysis revealed that FAI was strong predictor of serum Fetuin-A level. Serum Fetuin-A level was related with insulin resistance and ovarian hyperandrogenism in women with PCOS. These results suggest that Fetuin-A may have a role in triggering the processes leading to insulin resistance and androgen excess in PCOS. |
Databáze: | OpenAIRE |
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