Obesity and genetics
| Autor: | Semerci, C.N. |
|---|---|
| Jazyk: | turečtina |
| Rok vydání: | 2004 |
| Předmět: |
proopiomelanocortin
metabolic disorder multifactorial inheritance body composition obesity family heredity MC4R gene genetic analysis mortality leptin POMC gene clinical feature melanocortin 4 receptor monozygotic twins risk factor cardiovascular disease environmental factor genetic marker human gene leptin receptor conference paper Leptin Gene gene identification |
| Popis: | Obesity is a common multifactorial disease with which environmental and genetic factors interact. Obesity is a risk factor for early mortality, metabolic and cardiovascular complications. The strongest evidence for a genetic component of human obesity is the familial clustering and the high concordance of body composition in monozygotic twins. However, the role of genetic factors in obesity is complex. The human genes which cause monogenic obesity are encoding leptin, leptin receptor, POMC and MC4R. Another common form of human obesity is poligenic. Candidate genes studies and genome-wide scans were applied in searching for genes underlying poligenic obesity in humans. As a result, the mutations which were found account for only a few parts of obese cases. More genom wide scans with a high number of polymorphic marker are needed to identify another chromosomal region in obesity. Such studies will provide significant progresses for treatment and preventive medicine of human obesity. |
| Databáze: | OpenAIRE |
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