Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial
| Autor: | Serinken M, Eken C, Turkcuer I, Elicabuk H, Uyanik E, Schultz CH |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Acetaminophen/*administration & dosage/adverse effects
Adolescent Adult Analgesics Non-Narcotic/*administration & dosage/adverse effects Analgesics Opioid/*administration & dosage/adverse effects Double-Blind Method Emergency Service Hospital Female Humans Injections Intravenous Male Middle Aged Morphine/*administration & dosage/adverse effects Pain Measurement Prospective Studies Renal Colic/*drug therapy Young Adult |
| ISSN: | 0131-8187 |
| Popis: | OBJECTIVE: To determine the analgesic efficacy and safety of intravenous single-dose paracetamol versus morphine in patients presenting to the emergency department with renal colic. METHODS: A randomised double-blind study was performed to compare the efficacy of intravenous paracetamol (1 g) and 0.1 mg/kg morphine in patients with renal colic. The efficacy of the study drugs was measured by a visual analogue scale and a verbal rating scale at baseline and after 15 and 30 min. The adverse effects and need for rescue medication (1 μg/kg intravenous fentanyl) were also recorded at the end of the study. RESULTS: 133 patients were eligible for enrolment in the study, with 73 patients included in the final analysis (38 in the paracetamol group and 35 in the morphine group). The mean±SD age of the subjects was 30.2±8.6 years and 51 (70%) were men. The mean reduction in scores at 30 min after study drug administration was 63.7 mm (95% CI 57 to 71) for paracetamol and 56.6 mm (95% CI 48 to 65) for morphine. The difference between pain reduction scores for the two groups at 30 min was 7.1 mm (95% CI -18 to 4), demonstrating no statistical or clinical significance. Two adverse events (5.3%) were recorded in the paracetamol group and five (14.3%) in the morphine group (difference 9%, 95% CI -7% to 26%). CONCLUSION: Intravenous paracetamol is effective in treating patients presenting with renal colic to the emergency department. CLINICAL TRIALS REGISTRATION NO: ClinicalTrials.gov ID number NCT01318187. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|