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Objectives: The aim of the present study was to investigate the therapeutic effectsof systemic caffeic acid phenethyl ester treatment on oxidative stress and alveolarbone destruction in lipopolysaccharide (LPS)-induced periodontitis (EP) group inchronically stressed rats.Materials and Methods: Fourty male Sprague Dawley rats (EP-CS-CAPE) groupwere divided into four groups: 1) control group, 2) experimental periodontitis (EP),3) EP and chronic stress (CS) group (EP-CS), and 4) EP-CS treated with CAPE(EP-CS-CAPE). To induce periodontitis, LPS was administered into the buccalgingiva of the test groups, and pure saline was administered for the interleukin (IL)-1β levels were control group. Two test groups were exposed to restraint stress andone group of these groups was treated with only a single dose of CAPE (10mmol/kg). Likewise, saline was administered in the control, EP, and EP-CS groups.After 14 days, serum samples were collected from the heart, and all rats weresacrificed for analyses. Oxidative stress and interleukin (IL)-1β were investigated.The receptor activator of the nuclear factor kappa B ligand (RANKL) and alveolarbone loss were determined by immunohistochemical analysis.Results: The oxidative stress, alveolar bone loss, IL-1β and RANKL levels werefound significantly higher in the EP-CS group compared with control and EPgroups (p |
