The antiarrhythmic effect and clinical consequences of ischemic preconditioning
| Autor: | Evrengul H, Seleci D, Tanriverdi H, Kaftan A |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Angioplasty
Balloon Coronary Animals Anti-Arrhythmia Agents/therapeutic use Arrhythmias Cardiac/etiology/*prevention & control Coronary Artery Bypass Heat-Shock Proteins/biosynthesis Humans Ischemic Preconditioning Myocardial Myocardial Infarction/complications/metabolism/physiopathology/*therapy Potassium Channels Inwardly Rectifying/metabolism Ventricular Dysfunction Left/etiology/prevention & control cardiovascular system cardiovascular diseases |
| Popis: | Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been shown in experimental and clinical studies. Ischemic preconditioning decreases cardiac mortality markedly by preventing the development of left ventricular dysfunction and ventricular and supraventricular arrhythmias after acute myocardial infarction. Ischemia-induced opening of ATP-sensitive potassium channels and synthesis of stress proteins via activation of adenosine, bradykinin and prostaglandin receptors seem to be the possible mechanisms. By understanding the underlying mechanisms of ischemic preconditioning, it may be possible to develop new pharmacologic agents that cause ischemic preconditioning with antiischemic and antiarrhythmic properties without causing myocardial ischemia. |
| Databáze: | OpenAIRE |
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