Association of the neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence
| Autor: | Şengül,Cem., Erdal, M.E., Şengül Balcı,Ceyhan, Ay, O.I., Buber, A., Alaçam, Hüseyin., Ay, M.E., Herken, Hasan. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
neuropeptide Y
integumentary system alcoholism genetic association adult genotype Alcohol dependence DNA determination Neurexin gene frequency major clinical study Article neuropetide Y gene female male single nucleotide polymorphism controlled study human Polymorphism gene DNA extraction neurexin 3 gene |
| Popis: | Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved. |
| Databáze: | OpenAIRE |
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