The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats
| Autor: | Turgut S, Erken HA, Erken G, Ayada C, Genc O, Turgut G |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Animals
Chronic Disease Dietary Supplements Disease Models Animal Docosahexaenoic Acids/*pharmacology Growth Hormone/*blood Hypoxia/blood/*drug therapy/physiopathology Insulin-Like Growth Factor Binding Protein 3/blood Insulin-Like Growth Factor I/*metabolism Male Physical Exertion Rats Rats Wistar Time Factors |
| Popis: | BACKGROUND: In this study we examined the effects of docosahexaenoic acid (DHA) on growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in response to chronic hypoxia and exercise training in hypoxic conditions. METHODS: Thirty-five rats were divided into five groups; control group (C), hypoxia group (H), hypoxia-exercise group (HE), hypoxia-docosahexaenoic acid group (HD), hypoxia-exercise-docosahexaenoic acid group (HED). A treadmill exercise was performed as 30 m/min for 20 min/day, 5 days per week for 28 days at level grade for the exercising groups (HE and HED). DHA was given to the HD and HED groups every day orally (36 mg/kg). The animals, except for the C group, were exposed to hypoxia for 28 days. RESULTS: Serum levels of GH and IGF-I in the H group decreased after chronic hypoxia (p |
| Databáze: | OpenAIRE |
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