Histological and ultrastructural evidence for protective effects on aluminium-induced kidney damage by intraperitoneal administration of alpha-tocopherol
| Autor: | Kutlubay R, Oğuz EO, Güven C, Can B, Sinik Z, Tuncay OL |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Alum Compounds/*toxicity
Animals Antioxidants/*pharmacology Disease Models Animal Drug Antagonism Drug Therapy Combination Injections Intraperitoneal Kidney Diseases/chemically induced/*pathology/*prevention & control Male Microscopy Electron Transmission Nephrons/drug effects/*ultrastructure Rats Rats Wistar alpha-Tocopherol/*pharmacology |
| Popis: | The nephrotoxic actions of aluminium (Al) arise from its accumulation in the kidneys, with the resultant degeneration of the renal tubular cells. It has been suggested that Al generates reactive oxygen species that cause the oxidative deterioration of cellular lipids, proteins, and DNA. To test this hypothesis, we have here investigated the potential for a protective role of alpha-tocopherol (vitamin E) during short-term exposure of rats to Al. Al was administered intraperitoneally either alone or in combination with vitamin E at a different point of abdomen, and the alterations in the kidney tissue were analyzed histologically. The results reveal that significant light microscopical and ultrastructural damage is caused by Al, whereas with the immediate coadministration of vitamin E, there is a protective effect against this damage to the kidney tissue. In Al-alone group, the glomeruli and proximal tubuli and the Bowman capsules had swellings, adherence, hemorrhage, increase in mesangial matrix, and marked interstitial tissue fibrosis, indicating severe damage. In the Al and vitamin E immediate coinjected group, renal tubule cells were almost of a normal appearance. A slight stenosis was seen in the capsular area in the Malpighi corpuscules. The tubular organization and the cytoplasmic basophilia were also much the same as in the control group, with the lumen clearly visible in most of the cortical tubuli. The results highlight the need to reduce exposure to Al, with particular attention being paid to the known sources of Al. At the same time, the maintenance of a diet that is rich in vitamin E should be beneficial in the alleviation of Al toxicity. |
| Databáze: | OpenAIRE |
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