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S. pseudintermedius je običajno del normalne mikrobiote na koži in zunanjih sluznicah psov, hkrati pa glavni oportunistični patogen. Seve, ki vsebujejo gen mecA, imenujemo proti meticilinu odporni S. pseudintermedius (MRSP). Take seve so našli tudi pri ljudeh, kar pomeni, da je prav tako pomemben zoonotični pomen. Sevi MRSP so pogosto odporni proti več razredom protimikrobnih zdravil. V naši nalogi je najbolj obsežen rezistotip izolatov MRSP izkazoval odpornost proti kar 10 skupinam antibiotikov. Pri za meticilin občutljivih izolatih S. pseudintermedius (MSSP) se je pojavilo večje število različnih rezistitipov, vendar so bili ti rezistotipi manj obsežni. Slaba tretjina izolatov MSSP pa ni bila odporna proti niti enemu testiranemu antibiotiku. Najbolj obsežen rezistotip izolatov MSSP je obsegal 8 skupin antibiotikov. Večina izolatov v naši nalogi je pripadala sekvenčnemu tipu ST71, ki je tudi najbolj pogosto ugotovljen sekvenčni tip MRSP v Evropi. Drugi najbolj zastopan sekvenčni tip v Sloveniji je bil ST551. Oba najbolj zastopana sekvenčna tipa sta bila prisotna v različnih regijah po Sloveniji, kar nakazuje to, da sta razširjena po celotni državi. S. pseudintermedius is usually part of the normal microbiota on the skin and outer mucous membranes of dogs and, at the same time, a major opportunistic pathogen. Strains containing the mecA gene are called methicillin-resistant S. pseudintermedius (MRSP). Such strains have already been found in humans, which means that zoonotic significance is also possible. MRSP strains are often resistant to several classes of antimicrobial drugs. In our work, the most extensive resistotype of MRSP isolates showed resistance to as many as 10 groups of antibiotics. A large number of different resistotypes appeared in methicillin sensitive S. pseudintermedius (MSSP). However, these resistotypes were less extensive, and just under a third of MSSP isolates were not resistant to any of the antibiotics tested. The most extensive resistotype of MSSP isolates included 8 groups of antibiotics. Most of the isolates in our work belonged to the sequence type ST71, which is also the most frequently identified sequence type of MRSP in Europe. The second most represented sequence type in Slovenia was ST551. Both of the most represented sequence types were present in different regions of Slovenia, which indicates that they are widespread throughout the country. |
