| Popis: |
V magistrski nalogi sem raziskovala pretvorbo α-oksoketen ditioacetalov v prisotnosti joda s perfluorofenil hidrazinom. Pri tem so nastali 5-(metilsulfanil)-1-(pentafluorofenil)-1H-pirazoli. V nalogi je opisana in komentirana priprava izhodnih spojin. Naslovne pretvorbe so potekale v aprotičnih topilih in s 40–60 mol% joda kot promotorja. Izkoristki reakcij so v večini primerov zmerno dobri. Med izkoristki in stereoelektronskimi efekti substituentov ni jasne povezave. Vse nove produkte sem karakterizirala z 1H, 13C in 19F NMR, IR spektroskopijo, elementno analizo in/ali masno spektroskopijo visoke ločljivosti in izmerila njihovo tališča. In this master thesis the investigation of transformation of α-oxoketene dithioacetals in the presence of iodine with pentafluorophenyl hydrazine is presented. It resulted in formation of 5-(methylsulfanyl)-1-(pentafluorophenyl)-1H-pyrazoles. Synthesis of α-oxoketene dithioacetals is also reported and discussed. Their transformation occured in aprotic solvents and with 40–60 mol% of iodine as promotor. Most reactions gave good yields. There is no clear correlation between the yield and stereoelectronic effects of the substituents. All new substances were characterised by 1H-, 13C- and 19F-NMR, IR spectroscopy, elemental analysis and/or mass spectrometry and by measuring their melting point. |
