Performance characterization and acceleration of genome-mapping tools on HPC environments
| Autor: | Matzoros, Christos Konstantinos |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Moreto Planas, Miquel, Marco Sola, Santiago |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Informàtica::Enginyeria del software [Àrees temàtiques de la UPC]
Acceleration Vectorització Genoma humà--Mapatge Alineament de Seqüències Anàlisi de Rendiment Acceleració Vectorization HPC Performance Analysis Computació d'Altes Prestacions Human gene mapping High performance computing Sequence Alignment Càlcul intensiu (Informàtica) |
| Popis: | Nowadays, the efficient analysis and exploitation of genomic information is paramount to future advancements in the healthcare sector, such as better diagnosis techniques and the development of improved disease treatments. In the past decades, the exponential increase in the biological data production has fostered the development of more efficient genomic pipelines. For that, modern genome analysis requires better and more scalable algorithms, and improved high-performance implementations that can exploit current hardware accelerators. For most genome analysis pipelines, sequence mapping is one of the most computationally intensive and time-consuming processing stages. The ultimate goal of this work is to propose techniques to accelerate read mapping, leveraging novel algorithms and hardware vector extensions. In this thesis, we present a thorough performance characterization of the most widely-used genome-mapping tools and propose acceleration techniques that can effectively improve the performance of these tools. To that end, first, we identify the most time-consuming kernels, their performance bottlenecks, and the underlying causes of inefficiency. Afterwards, we design and implement an accelerated version of one of the most time-consuming steps: pairwise sequence alignment. For that, we propose to replace the classical dynamic-programming algorithm, used within these tools, with the recently proposed wavefront alignment algorithm (WFA). Moreover, we design and implement the first fully-vectorized version of the WFA, leveraging Intel's AVX2 and AVX-512 instructions, to further accelerate sequence-to-sequence alignment. As a result, we demonstrate that our vectorized WFA implementation outperforms the original scalar WFA implementation between 1.1x-2.4x. In turn, this renders speedups from 2.4x up to 826.7x compared to the most widely-used alignment algorithm, KSW2 (used within Minimap2 and Bwa-Mem2). We conclude that these tools can be significantly accelerated by selecting better algorithms (like the WFA) and leveraging fine-tuned implementations that can exploit hardware resources available in current high performance computing (HPC) processors. |
| Databáze: | OpenAIRE |
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