| Autor: |
Gondim, M.V., Wiltzer-Bach, L., Maurer, B., Banning, C., Arganaraz, E., Schindler, M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
J. Virol. 89, 12518-12524 (2015) |
| Popis: |
HIV-1 Nef-mediated CD4 downmodulation involves various host factors. We investigated the importance of AP-1, AP-2, AP-3, V1H-ATPase, β-COP and ACOT8 for CD4 downmodulation in HIV-1 infected shRNA-expressing CD4+ T cells and characterized direct interaction with Nef by FRET. Binding of lentiviral Nefs to CD4 and AP-2 was conserved and only AP-2 knockdown impaired Nef-mediated CD4 downmodulation from primary T cells. Altogether, among the factors tested, AP-2 is the most important player for Nef-mediated CD4 downmodulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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