Uptake kinetics of the somatostatin receptor ligand (86Y)DOTA-DPhe1-Tyr3-octreotide ([86Y]SMT487) using positron emission tomography in non-human primates and calculation of radiation doses of the 90Y-labelled analogue
| Autor: | Rösch, F., Herzog, H., Stolz, B., Brockmann, J., Köhle, M., Mühlensiepen, H., Marbach, P., Müller-Gärtner, H.-W. |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | European journal of nuclear medicine and molecular imaging 26, 353-366 (1999). European Journal of Nuclear Medicine; 1999, Vol. 26 Issue 4, p358 |
| Popis: | [[sup 90]Y]DOTA-DPhe[sup 1]-Tyr[sup 3]-octreotide ([[sup 90]Y]SMT487) has been suggested as a promising radiotherapeutic agent for somatostatin receptor-expressing tumours. In order to quantify the in vivo parameters of this compound and the radiation doses delivered to healthy organs, the analogue [[sup 86]Y]DOTA-DPhe[sup 1]-Tyr[sup 3]-octreotide was synthesised and its uptake measured in baboons using positron emission tomography (PET). [[sup 86]Y]DOTADPhe[sup 1]-Tyr[sup 3]-octreotide was administered at two different peptide concentrations, namely 2 and 100 micro g peptide per m2 body surface. The latter concentration corresponded to a radiotherapeutic dose. In a third protocol [[sup 86]Y]DOTA-DPhe[sup 1]-Tyr[sup 3]-octreotide was injected in conjunction with a simultaneous infusion of an amino acid solution that was high in L-lysine in order to lower the renal uptake of radioyttrium... |
| Databáze: | OpenAIRE |
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