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Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats. Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 µl) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 µg/4 µl) intracerebroventricularly (i.c.v.), 15 min before the test. Results: Linopirdine at a dose of 0.1 µg/4 µl significantly decreased immobilisation (p=0.003) and significantly increased swimming (p |
