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BACKGROUND: Gastrointestinal (GI) cancers (Ca) are a global health problem leading to high mortality around the world. Human organism presents a perfect defense against cancers by immune system. In this study, we aimed to evaluate the characteristics of the humoral and cellular immune systems in GI Ca patients. MATERIALS AND METHODS: Cellular and humoral immune parameters (CD3, CD4, CD8, CD16/CD56 and CD19 lymphocytes) were investigated in the peripheral blood of advanced 198 GI and hepatocellular cancer (HCC) patients by flow cytometry. RESULTS: CD8 lymphocyte levels were significantly increased in pancreatic and colorectal Ca groups (p< 0.05) and natural killer (CD16/CD56) lymphocytes were also significantly higher in gastric Ca, colorectal Ca and HCC patients compared to the controls (p< 0.01-0.05). Besides, CD19 lymphocytes were significantly lower in the pancreatic and colorectal Ca groups (p |
