Зміни гематологічного профілю у собак при різних клінічних формах демодекозу
| Autor: | Dovgiy, Yu., Zghozinska, О., Poberezhets, S. |
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| Jazyk: | ukrajinština |
| Rok vydání: | 2015 |
| Předmět: | |
| Popis: | Demodecosis is a parasitic skin disease that develops due to excessive multiplication of Demodex tick kind in the hair follicles and sebaceous glands. tick`s parasitism accompanied by mechanical, chemical irritation of the skin and the whole body as well. There are typical hematological changes with different clinical forms of demodecosis. Based on the actuality of the issue, the purpose of our study was to determine the hematological profile in dogs sick with localized and generalized forms of demodicosis. The work was carried out on the basis of Zhytomyr`s veterinary clinics. There were 30 dogs aged from 6 months up to 1 year that were involved to our experiment. Clinically healthy dogs were in the control group. The materials for the research were blood and serum. Counting of cellular blood elements showed that the number of red blood cells in animals infected with different clinical forms of demodecosis was lower than in the animals from control group. Reducing red blood cells of dogs may be the result of persistent presence of chronic inflammatory processes in the body inflicted by Demodecosis infection. The number of leukocytes in the blood of animals with a generalized form of demodecosis exceeded this number in healthy dogs in 1,82 times, with localized form - in 1,68 times. That fact pointed to inflammation and intoxication in the body of sick animals. leucograms analyzes of dogs we revealed a significant increase in the blood of sick animals the number of young neutrophils in 1,5 times eosinophils in 2,5-3 times, reducing the number of monocytes and lymphocytes in relation to dog control group. Reducing the number of lymphocytes in the blood testified about the development of immunodeficiency condition. According to the results of biochemical analysis, dynamic increase of total protein, including albumin was revealed in the blood of animals with Demodecosis infection. The activity of such enzymes as: aspartate aminotransferase (AST) in animals with localized and generalized forms of demodecosis comparing with healthy animals, was higher at 4,5 and 5,3 times; alanine aminotransferase (ALT) -in 3,5 and 3,7 times; alkaline phosphatase in 1,9 and 3 times; gamma-glutamyltransferase (GGT) to 37,5 and 61,2%. The content of glucose in the blood of infected dogs exceeded such content of healthy dogs by 3,8 and 16,5%, cholesterol by 22,6 and 61,9%, bilirubin 6,8 and 8,8%. The concentration of urea exceeded benchmarks in dogs with Demodecosis infection by 17,5 and 51,5%, creatinine – 2,3 and 4,3 times respectively. Проведені дослідження свідчать, про значні зміни показників гематологічного профілю в організмі собак, хворих на демодекоз. Причиною автори вважають вплив запальних процесів у тканинах, спричинених кліщем Demodex canis. При цьому зміни збоку клітин імунної системи найбільш яскраво виражені у тварин з генералізованою формою. У результаті біохімічних досліджень встановлено, що патологія печінки при локалізованій і генералізованій формах демодекозу є досить поширеною. Наявність печінкової недостатності вказує на необхідність включення гепатопротекторів до схеми лікування собак за демодекозу. |
| Databáze: | OpenAIRE |
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