New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents

Autor:	Akgün, H, Balkan, A, Erol, Kevser, Batu, Ö. S.
Přispěvatelé:	Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı
Jazyk:	angličtina
Rok vydání:	1998
Předmět:	Antihistaminic Drugs Xanthine Derivatives Theophylline Bronchodilator Activity Antiasthmatic Drugs 2 4-Penta-Nediones 3 5-Dimethylisoxazoles
Popis:	WOS: 000075057400007 PubMed ID: 9689423 Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated using the method based on inhibition of acetylcholine and histamine-induced contractions in guinea pig trachea. None of the compounds were effective on acetylcholine-induced contractions. However, the compounds 4d, 4e, 5d and 5c were potent inhibitors of the bronchospasm induced by histamine, whereas the others (4b, 4c, 5b and 5c) were weak inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3106::2c22648b0fe9519b7f42ccc0c912a826 https://hdl.handle.net/11421/13284 Zobrazit plný text záznamu