Citalopram Induces Reproductive Toxicity in Male Rats
| Autor: | Ilgın, Sinem, Aydoğan-Kılıc, G., Baysal, Merve, Kılıç, Volkan, Korkut, Büşra, Uçarcan, Şeyda, Atlı Eklioğlu, Özlem |
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| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ilgın, Sinem, Aydoğan-Kılıc, G., Kılıç, Volkan, Uçarcan, Şeyda, Atlı Eklioğlu, Özlem |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Popis: | WOS: 000399733100002 PubMed ID: 28398617 Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects of CTL on the reproductive system of male rats. Methods: For this purpose, CTL was administered at 5, 10, and 20 mg/kg/day to rats orally for 28 days. Sperm concentration, motility, and morphology were investigated using a computer-assisted sperm analysis system, and sperm DNA damage was detected using a Comet assay. The testes were histopathologically examined. Serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels were measured and the oxidative status of testes was investigated. Results: Our results showed that sperm concentration was reduced, and abnormal sperm morphology and sperm DNA damage were increased in CTL-administered groups. Additionally, histopathological changes were observed in the testes of CTL-administered rats. Luteinizing hormone levels were increased in CTL-administered groups, while testosterone levels were increased in the 5 and 10 mg/kg CTL-administered groups. Decreased glutathione signaled enhanced oxidative stress in the 10 and 20 mg/kg CTL-administered groups. Conclusion: Thus, we concluded that CT induced testicular damage in male rats; this testicular damage was accompanied by oxidative stress and hormonal changes, which are considered as the important causes of reproductive disorders |
| Databáze: | OpenAIRE |
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