| Popis: |
Objective: Psoriasis vulgaris is a chronic inflammatory T-cell mediated immune dermatosis characterized by a high epidermal cell turnover, which results in a typical epidermal hyperplasia. The aim of this study is to show the correlation between p53 protein accumulation that provides epidermal hyperproliferation and mast cell count in the pathogenesis of psoriasis vulgaris. Material and Methods: In this study, punch biopsies from 56 psoriasis cases have been evaluated. The presence of mast cells in with metachromatic granules are with 1% toluidin blue stain solution has been investigated. In addition, mast cells that show immunoreactions to "mast cell tryptase" antibody have been observed and proportion of p53 staining in epidermal keratinocytes has been determined. Results: In psoriasis cases, mast cells count (mean) and proportion of p53 staining (mean) were 69.3 ± 21.5/mm2 and 602.3 ± 192.1 respectively, in the group without any treatment (n: 20); 57.1 ± 27.5/mm2 and 373.1 ± 193.6 respectively in the group treated with psolaren plus UVA radiation (n: 36). In the control group, it was demonstrated that mast cells count was 74.6 ± 25.9/mm2 (mean) and proportion of p53 staining was 176.4 ± 109.2 (mean). No correlation has been found between mast cell count and proportion of p53 staining in psoriasis groups. However, a moderate correlation (r= 0.30 P< 0.05) has been found between mast cell count and proportion of p53 staining in the control group. Conclusion: Since the correlation obtained between mast cell number and proportion of p53 staining in the healthy skin was not observed psoriasis cases, it can be thought that these variables take part in different pathways of pathogenesis. © 2011 by Türkiye Klinikleri. |
