c-Kit (CD117) expression in classic Kaposi's sarcoma

Autor: Kandemir, N. O., Gun, B. D., Bahadir, B., Yurdakan, G., Ozdemir, N., Karadayi, N., Ozdamar, S. O.
Přispěvatelé: Zonguldak Bülent Ecevit Üniversitesi
Jazyk: angličtina
Rok vydání: 2010
Popis: WOS: 000278564200016
PubMed: 19874361
Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.
Databáze: OpenAIRE
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