| Popis: |
Atherosclerosis rates are higher in adult diabetic patients than normal population and is one of the major causes of death. The main reason of this is that serum lipid and lipoprotein levels are impaired, increasing the risk for atherosclerosis. For this reason, it is needed to investigate the alterations of serum lipid parameters in patients with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) and their effects on atherosclerosis and coronary artery disease (CAD). In this study, we measured lipid parameters, HbA1c, insulin and CRP levels in IGT and IFG patients and aimed to evaluate if they are under risk to develop atherosclerosis and diabetes mellitus (DM). Serum triglyceride, insulin and CRP levels were found to be significantly high in IGT group, and serum triglyceride, HbA1c, insulin and CRP in IFG group, than the control group. Serum HDL-cholesterol level was found to be significantly low in both study groups than the control. While serum triglyceride level was higher in IFG group than IGT group, LDL-cholesterol and HbA1c levels were significantly higher in IGT group than IFG group. Also BMI values of control group were found to be significantly lower than both IFG and IGT groups. The results we obtained from this study showed that IFG and IGT patients are under high risk for atherosclerosis and CAD due to dyslipidemia and increased CRP levels and increased level of HbA1c may show that oxidant effects may be increased related with non-enzymatic glycosidation and related metabolic stress. Also CRP level may be a good parameter for follow-up of disease and complications in IGT and IFG patients. |
