ANTIDIABETIC PROPERTIES OF QUEBECOL AS NATURAL PHENOLIC COMPOUND: alpha -GLYCOSIDASE AND alpha -AMYLASE METABOLIC ENZYMES INHIBITION PROPERTIES

Autor:	Kocyigit, Umit Muhammet
Přispěvatelé:	[Kocyigit, Umit Muhammet] Sivas Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Quebecol alpha-amylase enzyme inhibition alpha-glycosidase
Popis:	WOS: 000461270800022 This study aims to examine the inhibitory effect of Quebecol on alpha-glycosidase and alpha-amylase enzyme activities in comparison with acarbose as a standard. IC50 amounts were obtained by using the Quebecol-Induced Activity (%) - [Quebecol] graph and the Lineweaver-Burk graph. The IC50 values obtained with Quebecol were 28.56 nM for alpha-glycosidase and 211.82 nM for alpha-amylase, while the mean K-i value was 8.04 nM for alpha-glycosidase. The results of our study are expected to contribute to pharmaceutical research and pharmacological applications by providing insight into the biological effects of Quebecol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______3104::ed8a3609b88e3c531cfb8067ce35eb9d https://hdl.handle.net/20.500.12418/6040 Zobrazit plný text záznamu