Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure
| Autor: | Gulati, Ankur, Japp, Alan G, Raza, Sadaf, Halliday, Brian P, Jones, Daniel A, Newsome, Simon, Ismail, Nizar A, Morarji, Kishen, Khwaja, Jahanzaib, Spath, Nick, Shakespeare, Carl, Kalra, Paul R, Lloyd, Guy, Mathur, Anthony, Cleland, John G F, Cowie, Martin R, Assomull, Ravi G, Pennell, Dudley J, Ismail, Tevfik F, Prasad, Sanjay K |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Zdroj: | Gulati, A, Japp, A G, Raza, S, Halliday, B P, Jones, D A, Newsome, S, Ismail, N A, Morarji, K, Khwaja, J, Spath, N, Shakespeare, C, Kalra, P R, Lloyd, G, Mathur, A, Cleland, J G F, Cowie, M R, Assomull, R G, Pennell, D J, Ismail, T F & Prasad, S K 2018, ' Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure ', Circulation: Cardiovascular Imaging, vol. 11, no. 9, pp. e007722 . https://doi.org/10.1161/CIRCIMAGING.118.007722 |
| DOI: | 10.1161/CIRCIMAGING.118.007722 |
| Popis: | BACKGROUND: Myocardial fibrosis, identified by late gadolinium enhancement cardiovascular magnetic resonance, predicts outcomes in chronic heart failure (HF). Its prognostic significance in new-onset HF and reduced left ventricular ejection fraction (LVEF) is unclear. We investigated whether the pattern and extent of fibrosis predict survival in new-onset HF and reduced LVEF of initially uncertain pathogenesis.METHODS AND RESULTS: Of 120 consecutive patients with new-onset (CONCLUSIONS: The pattern and extent of myocardial fibrosis predict adverse outcomes in new-onset HF and reduced LVEF. In contrast, the absence of fibrosis portends a durable warranty period with a low incidence of adverse events. These findings support a role for late gadolinium enhancement cardiovascular magnetic resonance in the early risk stratification of patients with HF of uncertain pathogenesis. |
| Databáze: | OpenAIRE |
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