| Autor: |
Halken, Susanne, Agertoft, Lone, Seidenberg, Jürgen, Bauer, Carl-Peter, Payot, François, Martin-Muñoz, Maria Flora, Bartkowiak-Emeryk, Małgorzata, Vereda, Andrea, Jean-Alphonse, Stephanie, Melac, Michel, Le Gall, Martine, Wahn, Ulrich |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Halken, S, Agertoft, L, Seidenberg, J, Bauer, C-P, Payot, F, Martin-Muñoz, M F, Bartkowiak-Emeryk, M, Vereda, A, Jean-Alphonse, S, Melac, M, Le Gall, M & Wahn, U 2010, ' Five-grass pollen 300IR SLIT tablets: efficacy and safety in children and adolescents ', Pediatric Allergy and Immunology, vol. 21, no. 6, pp. 970-6 . https://doi.org/10.1111/j.1399-3038.2010.01050.x |
| DOI: |
10.1111/j.1399-3038.2010.01050.x |
| Popis: |
The efficacy and safety of five-grass pollen 300IR sublingual immunotherapy (SLIT) tablets (Stallergènes SA, France) have previously been demonstrated in paediatric patients. This report presents additional data concerning efficacy at pollen peak, efficacy and safety according to age, nasal and ocular symptoms, use of rescue medication, satisfaction with treatment and compliance. Children (5-11 yr) and adolescents (12-17 yr) with grass pollen-allergic rhinoconjunctivitis were included in a multinational, randomized, double-blind, placebo-controlled study and received either a 300IR five-grass pollen tablet or placebo daily in a pre- (4 months) and co-seasonal protocol. The severity of six symptoms (sneezing, rhinorrhoea, nasal congestion, nasal and ocular pruritis, and tearing) was scored, and rescue medication use was recorded daily during the pollen season. Patient satisfaction was recorded at the season end. A total of 161 children and 117 adolescents were evaluated (n = 267). 300IR SLIT was effective over the whole season (p = 0.0010) and at the pollen peak (p = 0.0009). The adjusted mean difference between 300IR and placebo groups was significant for both nasal (p = 0.0183) and ocular (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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