| Autor: |
Pareek, Manan, Nielsen, Mette Lundgren, Leósdóttir, Margrét, Nilsson, Peter M, Olsen, Michael Hecht |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Pareek, M, Nielsen, M L, Leósdóttir, M, Nilsson, P M & Olsen, M H 2016, ' Independent prognostic value of left ventricular mass, diastolic function, and fasting plasma glucose : a population-based cohort stydy ', Journal of Hypertension, vol. 34, no. e-suppl. 1, OS 27-06, pp. e250 . https://doi.org/10.1097/01.hjh.0000500566.79672.d9 |
| DOI: |
10.1097/01.hjh.0000500566.79672.d9 |
| Popis: |
OBJECTIVE: To explore the independent prognostic value of left ventricular (LV) mass, diastolic function, and fasting plasma glucose (FPG) for the prediction of incident cardiac events in a random population sample.DESIGN AND METHOD: 415 women and 999 men aged 56-79 years, included between 2002-2006, underwent echocardiography based on groups defined by FPG, i.e. normal (NFG): FPG ≤ 6.0 mmol/L; impaired (IFG): FPG 6.1-6.9 mmol/L; and diabetes mellitus (DM): FPG ≥ 7.0 mmol/L, self-reported DM, and/or on anti-diabetic drugs. Additive prognostic value of FPG category and echocardiography (LV mass index (LVMI), LV hypertrophy (LVH), averaged E/é, and diastolic function graded as normal, grade 1, or grade 2 + 3 diastolic dysfunction) to a prediction model with traditional cardiovascular (CV) risk factors was assessed using Cox proportional hazards regression. Cardiac events were defined as myocardial infarction, coronary revascularization, or heart failure.RESULTS: 37 % were classified as NFG, 26 % as IFG, and 37 % as DM. Median LVMI and E/é were 86 [74-102] g/m and 8 [6-10], respectively. Over a median follow-up time of 7.8 [7.2-8.7] years, 181 events occurred. The simple prediction model included age, gender, systolic blood pressure, heart rate, previous CV disease, and use of CV medication. Addition of averaged E/é (likelihood-ratio c 11.69, p CONCLUSIONS: LVMI and E/é, but not FPG category provided additional adverse prognostic value on top of traditional CV risk factors. The combination of both glucometabolic and echocardiographic abnormalities was associated with a progressively greater risk of cardiac events. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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