Nedsat koenzym Q10 kan være årsag til statinassocieret myopati

Autor:	Nielsen, Mette Lundgren, Pareek, Manan, Henriksen, Jan Erik
Jazyk:	dánština
Rok vydání:	2011
Předmět:	Muscular Diseases Risk Factors Ubiquinone Muscles fungi food and beverages Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Mitochondria Muscle
Zdroj:	Nielsen, M L, Pareek, M & Henriksen, J E 2011, ' Nedsat koenzym Q10 kan være årsag til statinassocieret myopati ', Ugeskrift for Laeger, bind 173, nr. 46, s. 2943-8 .
Popis:	Statin treatment can cause muscular side effects. It has been suggested that the mechanism is reduced synthesis of coenzyme Q10 (coQ10) and a subsequent dysfunction of the respiratory chain. A literature review resulted in insufficient evidence supporting this theory. It is uncertain whether intramuscular levels of coQ10 and mitochondrial function are affected by statin therapy and whether the symptoms of myopathy can be alleviated with coQ10 supplementation. Nevertheless, due to a favourable safety profile, coQ10 can be tested in patients whose muscular symptoms cannot be managed otherwise.
Databáze:	OpenAIRE
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