| Autor: |
Holbech, Henrik, Kinnberg, Karin Lund, Petersen, Gitte |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Zdroj: |
Holbech, H, Kinnberg, K L & Petersen, G 2011, VALIDATION REPORT (PHASE 2) FOR THE FISH SEXUAL DEVELOPMENT TEST FOR THE DETECTION OF ENDOCRINE ACTIVE SUBSTANCES . OECD Environment, Health and Safety Publications, vol. 142, Organisation for Economic cooporation and development . < http://www.oecd.org/officialdocuments/displaydocumentpdf/?cote=ENV/JM/MONO(2011)23&doclanguage=en > |
| Popis: |
This document presents the validation report (phase 2) of the Fish Sexual Development Test (FSDT). TheFish Sexual Development Test (FSDT) covers a life-stage where sexual development is particularlysensitive to perturbation caused by endocrine active chemicals. The chemical exposure lasts for about 60days, at the end of which endpoints of ecological relevance like the sex ratio of the exposed fish iscalculated and the biomarker endpoint vitellogenin is measured in individual animals.In 2003, Denmark, on behalf of the European Nordic countries, proposed a new project o develop a TestGuideline on the fish sexual development test to the Working Group of the National Coordinators of theTest Guidelines Programme (WNT). The project was included on the Test Guidelines workplan in 2003,and extensive validation of the test method was carried out until 2009. Two validation studies wereperformed, including chemicals representing various modes of action (oestrogen, (anti-)androgen,aromatase inhibitor) and negative chemicals. The chemicals tested in the phase 2 validation included theweakly active oestrogenic 4-tert-octylphenol and the androgenic dihydrotestosterone for the speciesmedaka and zebrafish, and the weakly active oestrogenic 4-tert-pentylphenol, the anti-androgenicflutamide and the oestrogenic 17β-estradiol for the stickleback.The validation has been overseen by a validation management group for Eco-toxicity testing (VMG-eco)and a fish drafting group. A peer-review of the validation has been organised in 2011 and the report isavailable in the Series on Testing and Assessment as No.143. The draft validation report has been endorsedby the WNT at its meeting held on 12-14 April 2011. [The Joint Meeting of the Chemicals Committee andWorking Party on Chemicals, Pesticides and Biotechnology agreed to its declassification on 22 June 2011]. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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