Short QTc Interval in Males with Klinefelter Syndrome:Influence of CAG Repeat Length, Body Composition, and Testosterone Replacement Therapy
| Autor: | Jorgensen, I. N., Skakkebæk, A., Andersen, N. H., Pedersen, L. N., Hougaard, D. M., Bojesen, A., Trolle, C., Gravholt, C. H. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Adult body composition hypothalamus-pituitary-testicular axis hypogonadism cardiology ECG ANDROGEN RECEPTOR POLYMORPHISM X-CHROMOSOME INACTIVATION HEART-RATE MORTALITY PREVALENCE PHENOTYPE HORMONES MEN AGE body composition ECG Incidence Arrhythmias Cardiac/diagnosis Comorbidity Testosterone/therapeutic use hypothalamus-pituitary-testicular axis Denmark/epidemiology Trinucleotide Repeat Expansion/genetics Age Distribution Risk Factors cardiology Genetic Predisposition to Disease/epidemiology Case-Control Studies Hormone Replacement Therapy/statistics & numerical data hypogonadism Humans Educational Status cardiovascular diseases Electrocardiography/statistics & numerical data |
| Zdroj: | Jorgensen, I N, Skakkebæk, A, Andersen, N H, Pedersen, L N, Hougaard, D M, Bojesen, A, Trolle, C & Gravholt, C H 2015, ' Short QTc Interval in Males with Klinefelter Syndrome : Influence of CAG Repeat Length, Body Composition, and Testosterone Replacement Therapy ', Pacing and Clinical Electrophysiology, vol. 38, no. 4, pp. 472-482 . https://doi.org/10.1111/pace.12580 |
| DOI: | 10.1111/pace.12580 |
| Popis: | Background Klinefelter syndrome (KS) is a sex chromosomal aneuploidy (47,XXY) affecting 1/660 males. Based on findings in Turner syndrome, we hypothesized that electrocardiogram (ECG) abnormalities would be present in males with KS. Objective To investigate ECGs in males with KS and compare with controls. Methods Case control study of 62 males with KS and 62 healthy males matched on age. The primary outcome parameter was a difference in the ECG presentation between the two groups. The ECGs were analyzed by one blinded examiner (intraobserver variability 0.2-2.1%). The QT-interval was measured using "teach-the-tangent" method excluding the U-wave. QTc was calculated using Bazett's equation, Hodges' equation, and a linear regression model. Body mass index, abdominal fat, and muscle mass as well as sex hormone levels were secondary parameters. The prevalence of mutations in genes related to short QT syndrome was determined in participants with a QTc < 330 ms. Results Compared to controls, the QTc-interval was shorter (P = 0.02-0.06) in males with KS depending on the applied correction method. QTc was shortest among testosterone (T)-treated males with KS, while untreated and thus hypogonadal KS had QTc interval comparable to controls. No mutations in genes related to short QT syndrome were found. Conclusion We found short QTc interval in males with KS, with further shortening of the QTc interval by T. These results suggest that genes on the X chromosome could be involved in regulation of the QTc interval and that T treatment may aggravate this mechanism. |
| Databáze: | OpenAIRE |
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