| Zdroj: |
Hawa, M I, Kolb, H, Schloot, N, Beyan, H, Paschou, S A, Buzzetti, R, Puente, D M, De Leiva, A, Yderstraede, K, Beck-Neilsen, H, Tuomilehto, J, Sarti, C, Thivolet, C, Hadden, D, Hunter, S, Schernthaner, G, Scherbaum, W A, Williams, R, Brophy, S, Pozzilli, P, Leslie, R D & on behalf of the Action LADA consortium 2013, ' Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype : Action LADA 7 ', Diabetes Care, vol. 36, no. 4, pp. 908-913 . https://doi.org/10.2337/dc12-0931 |
| Popis: |
OBJECTIVESSpecific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non-insulin requiring, e.g., with latent autoimmune diabetes (LADA). We aimed to characterize adult-onset autoimmune diabetes.RESEARCH DESIGN AND METHODSWe consecutively studied 6,156 European diabetic patients attending clinics within 5 years of diagnosis (age range, 30-70 years) examined cross-sectionally clinically and for GAD antibodies (GADA) and antibodies to insulinoma-associated antigen-2 (IA-2A) and zinc-transporter 8 (ZnT8A).RESULTSOf 6,156 patients, 541 (8.8%) had GADA and only 57 (0.9%) IA-2A or ZnT8A alone. More autoantibody-positive than autoantibody-negative patients were younger, leaner, on insulin (49.5 vs. 13.2%), and female (P 200 WHO IU) (n = 403) compared with low (n = 138) titer were female, lean, and insulin treated (54.6 vs. 39.7%) (P |
