Correlation of CD8 infiltration and expression of its checkpoint proteins PD-L1 and PD-L2 with the stage of cervical carcinoma
| Autor: | Carvalho, Maria O. O., Nicol, Alcina F., Oliveira, Nathalia S., Cunha, Cynthia B., Amaro Filho, Sergio M., Russomano, Fabio B., Portari, Elizabeth A., Nuovo, Gerard J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Repositório Institucional da FIOCRUZ (ARCA) Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| Popis: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evando Chagas. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evando Chagas. LApClin DST/AIDS. Rio de Janeiro, RJ. Brasil. Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil. Instituo Nacional de Câncer. Divisão de Genética. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Patologia Cervical e Colposcopia. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. Ohio State University. Comprehensive Cancer Center. Columbus, Ohio, USA. The importance of CD8 infiltration for cancer prognosis has been underscored lately by the increased use of checkpoint inhibitors in patients with invasive tumors. The objective of this study was to determine if CD8 infiltration and the expression of two key checkpoint proteins, PD-L1 and PD-L2, varied between early stage (FIGO IA-IIA) and advanced stage (FIGO IIB-IVA) cervical cancer. A tissue micro-array with 61 cervical specimens was analyzed through immunohistochemistry for PD-L1, PD-L2 and CD8 using CD1a (antigen presenting cells) as an internal control. Infiltration of both CD8 and CD1a was evident in control, benign tissues that showed little to no PD-L1 and PD-L2 reactivity. In samples of invasive cervical cancers, there was a three-fold increase in the number of CD8 cells with an increase in the expression of both PD-L1 and PD-L2 (P |
| Databáze: | OpenAIRE |
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