Cardiac and pulmonary involvement on acute and chronic schistosomiasis in mice fed high-fat diet
| Autor: | Góes, Vanessa Coelho de |
|---|---|
| Přispěvatelé: | Silva, José Roberto Machado e, Neves, Renata Heisler, Lacerda, Márcia Barbosa águila Mandarim de, Maior, Claudia Maria Antunes Uchôa Souto |
| Jazyk: | portugalština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T18:12:55Z No. of bitstreams: 1 Vanessa Coelho de Goes Dissertacao completa.pdf: 5962667 bytes, checksum: 0bb9490cb3585d0a3be2af0fed26a0ef (MD5) Made available in DSpace on 2021-01-05T18:12:55Z (GMT). No. of bitstreams: 1 Vanessa Coelho de Goes Dissertacao completa.pdf: 5962667 bytes, checksum: 0bb9490cb3585d0a3be2af0fed26a0ef (MD5) Previous issue date: 2011-03-14 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro The aim of this work was to evaluate changes in heart and lung tissue of mice underlying dyslipidemia, schistosomiasis and their controls euthanized in 9th (acute phase) and 17th (chronic phase) weeks post-infection. Four groups of mice were studied, according to the diet and time of infection: standard chow (SCa and SCc), high-fat chow (HFCa and HFCc), infected standard chow (ISCa and ISCc) and infected high-fat chow (IHFCa and IHFCc). The heart and lungs were extracted, sectioned and their fragments passed by histological procedures and were stained with Hematoxilin and Eosin and Picrosirius Red. Histopathological analysis was performed on both organs, and also stereological (optical disector) and morphometric studies (vessels, cardiomyocytes and quantification of collagen) of the heart. Groups were compared by: Student T and/or ANOVA tests. All animals fed high-fat chow, infected or not, had a lower numerical density and total number of cardiomyocytes (p |
| Databáze: | OpenAIRE |
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