Botulinum toxin type A for cephalic cutaneous allodynia in chronic migraine: a randomized, double-blinded, placebo-controlled trial
| Autor: | Hollanda, Luciano, Monteiro, Larissa, Melo, Ailton de Souza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.4081/ni.2014.5133 |
| Popis: | Texto completo: acesso restrito. p.70-73 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2015-03-18T15:48:56Z No. of bitstreams: 1 Luciano Hollanda.pdf: 644979 bytes, checksum: 299f86c2734101543b25e8ce1e69c38d (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2015-03-19T15:04:36Z (GMT) No. of bitstreams: 1 Luciano Hollanda.pdf: 644979 bytes, checksum: 299f86c2734101543b25e8ce1e69c38d (MD5) Made available in DSpace on 2015-03-19T15:04:36Z (GMT). No. of bitstreams: 1 Luciano Hollanda.pdf: 644979 bytes, checksum: 299f86c2734101543b25e8ce1e69c38d (MD5) Previous issue date: 2014 Cephalic allodynia (CA) can be observed in 50-70% of patients with chronic migraine (CM). The aim of this trial was to assess the efficacy of botulinum toxin type A (Botx-A) in the treatment of CA associated with CM. In this placebo-controlled trial, patients were randomized either into Botx-A or 0.9% saline injections and efficacy measures were assessed every 4 weeks for 3 months. Efficacy endpoints were number of migraine episodes associated with CA, changes from baseline in visual analogical scale scores for pain (VAS) and frequency of common analgesics use for migraine. A total of 38 subjects were randomized to saline (n=18) or Botx-A (n=20). There were no significant differences in baseline between active intervention or placebo groups regarding mean age, number of headache episodes [mean 12.1 (9.22) and 17.00 (9.69) respectively; P=0.12], pain severity as measured by the VAS or frequency of analgesic use for headache episodes. Efficacy analysis showed that Botx-A injections led to an important decrease from baseline in the mean migraine episodes associated with CA after 12 weeks (5.20 versus 11.17; P=0.01). Also, VAS scores and frequency of analgesics use for headache were significantly reduced in the Botx-A group. This study suggests that Botx-A injections are superior to saline in the treatment of CA associated with CM, with mild self limited side effects. |
| Databáze: | OpenAIRE |
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