Antiretroviral adherence and virologic suppression in partnered and unpartnered HIV-positive individuals in southern Brazil
| Autor: | Melo, Marineide Gonçalves de, Varella, Ivana Rosângela dos Santos, Gorbach, Pamina M., Sprinz, Eduardo, Santos, Breno Riegel dos, Rocha, Tauí de Melo, Moesch, Mariana Riegel de Pádua Simon, Azambuja, Marcelo Almeida, Lira, Rita, Seter, Maria Cristina Chaves, Baker, Zoë, Kerin, Tara, Nielsen-Saines, Karin A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| Popis: | Background: An undetectable serum HIV-1 load is key to effectiveness of antiretroviral (ARV) therapy, which depends on adherence to treatment. We evaluated factors possibly associated with ARV adherence and virologic response in HIV-infected heterosexual individuals. Methods: A cross-sectional study was conducted in 200 HIV-1 serodiscordant couples and 100 unpartnered individuals receiving ARV treatment at a tertiary hospital in southern Brazil. All subjects provided written informed consent, answered demographic/behavioral questionnaires through audio computer-assisted self-interviews (ACASI), and collected blood and vaginal samples for biological markers and assessment of sexually transmitted infections (STIs). HIV-negative partners were counseled and tested for HIV-1. Results: The study population mean age was 39.9 years, 53.6% were female, 62.5% were Caucasian, 52.6% had incomplete or complete elementary education, 63.1% resided in Porto Alegre. Demographic, behavioral and biological marker characteristics were similar between couples and single individuals. There was an association between adherence reported on ACASI and an undetectable serum viral load (P |
| Databáze: | OpenAIRE |
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