Toxicon
| Autor: | Silva, Rejane Maria Lira da, Prianti Junior, Antonio C. G., Ribeiro, Wellington, Martins, Rodrigo A. B. Lopes, Franceschi, Julia Prado, Simioni, Léa Rodrigues, Höfling, Maria Alice da Cruz, Leite, Gildo B., Hyslop, Stephen, Cogo, José C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/S0041-0101(03)00002-3 |
| Popis: | Texto completo: acesso restrito. p. 595–603 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-06T14:40:00Z No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5) Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-23T18:15:15Z (GMT) No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5) Made available in DSpace on 2014-01-23T18:15:16Z (GMT). No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5) Previous issue date: 2003 Bothrops leucurus is a poorly studied pitviper found in northeastern Brazil. We examined the action of B. leucurus venom (5–100 μg/ml) on contractile responses in chick biventer cervicis preparations. Muscle damage was assessed by quantifying the release of creatine kinase (CK) and by histological analysis. B. leucurus venom dose-dependently inhibited the contractile responses of indirectly stimulated preparations, the maximum inhibition with 100 μg of venom/ml being 74.0±6.6% (mean±SEM) after 120 min. The venom also reduced contractures to exogenous acetylcholine (55 and 110 μM) and K+ (13.4 mM) (85–100% reduction with 100 μg of venom/ml) and increased the release of CK (348±139 U/ml in controls vs 1260±263 U/ml with 20 μg of venom/ml after 120 min, p |
| Databáze: | OpenAIRE |
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