Neuroimmunomodulation
| Autor: | Medeiro, Jairza Barreto, Deiró, Adenilda Queirós Santos, Cabral Filho, José Eulálio, Silva, Wylla Tatiana Ferreira e, Leandro, Carol Góis, Deiró, Tereza Cristina Bomfim de Jesus, Castro, Raul Manhães de, Castro, Célia Maria Machado Barbosa de |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1159/000112047 |
| Popis: | Texto completo: acesso restrito. p. 229-234 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-18T14:42:04Z No. of bitstreams: 1 10.1159-000112047.pdf: 113633 bytes, checksum: f0ad4752e8eccb8d4fa436c01c0a434f (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-02-19T18:42:19Z (GMT) No. of bitstreams: 1 10.1159-000112047.pdf: 113633 bytes, checksum: f0ad4752e8eccb8d4fa436c01c0a434f (MD5) Made available in DSpace on 2014-02-19T18:42:19Z (GMT). No. of bitstreams: 1 10.1159-000112047.pdf: 113633 bytes, checksum: f0ad4752e8eccb8d4fa436c01c0a434f (MD5) Previous issue date: 2007 Background/Aims: Neonatal malnutrition induces metabolic and endocrine changes that have beneficial effects on the neonatal in the short term but, in the longer term, these alterations lead to maladaptations. We investigated the effect of neonatal malnutrition on immune responses in adult rats submitted or not to an aggressiveness test. Methods: Male Wistar rats were distributed to one of two groups according to their mothers’ diet during lactation: the well-nourished group (group C, n = 42, receiving 23% of protein) and the malnourished group (group MN, n = 42, receiving 8% of protein). After weaning, all rats received normoproteic diet. Ninety days after birth, each group was subdivided into three subgroups: control rats (n = 14, respectively), aggressive rats (n = 14, respectively) and rats receiving foot shock (FS; n = 14, respectively). Plasma corticosterone concentration was measured after FS sessions. Leukocyte counts and humoral immunity were evaluated. Results: In neonatal malnourished animals, FS-induced stress reduced plasma corticosterone concentration. Intraspecific aggressiveness induced alterations in leukocyte counts and antibody titers 7 and 15 days after immunization. Neonatal malnourished animals showed no changes in the immune parameters evaluated. Conclusions: Expression of intraspecific aggressiveness activates the immune system. Neonatal malnutrition seems to have a long-lasting effect on components of both neuroendocrine and immune functions. |
| Databáze: | OpenAIRE |
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