SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS

Autor: Thomazella, Nathalia A. [UNESP], Lemos, Sahra C. [UNESP], Souza, Ronan F. F. de [UNESP], Souza, Rodrigo A. de [UNESP], Mauro, Antonio E. [UNESP], Carlos, Iracilda Z. [UNESP], Netto, Adelino V. G. [UNESP]
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: portugalština
Rok vydání: 2018
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Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0100-4042
Popis: Made available in DSpace on 2019-10-04T12:32:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01. Added 1 bitstream(s) on 2021-07-15T14:34:57Z : No. of bitstreams: 1 S0100-40422018001001150.pdf: 860071 bytes, checksum: 0e81af1a835dbfe60bd7f7ad77feacf4 (MD5) The halide bridge cleavage reaction of the [Pd(C-2,N-bzox)(mu-Cl)](2). compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C-2,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd((C-2,N-bzox)(X)(L)] = {X = Br- (2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and H-1- and C-13{H-1}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. Hie cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin. Univ Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim, BR-14800060 Araraquara, SP, Brazil Univ Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, Brazil Univ Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim, BR-14800060 Araraquara, SP, Brazil Univ Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, Brazil
Databáze: OpenAIRE
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